Acute chromosomal DNA damage after radiation exposure: reply

Acute chromosomal DNA damage in human lymphocytes after radiation exposure in invasive cardiovascular procedures.

AIMS We evaluated whether radiation exposure during interventional cardiovascular procedures can induce damage to deoxyribonucleic acid (DNA). METHODS AND RESULTS Micronucleus assay (MN) was performed as biomarker of chromosomal damage and intermediate endpoint in carcinogenesis. Seventy-two patients (54 males, age = 63.8 +/- 10.5 years) undergoing a wide range of radiation exposure during in...

Radiation track and DNA damage

Effect of Exposure to Ionizing Radiation on Biomarker of Oxidative Damage of DNA

Introduction: one of the most important complications of exposure to ionizing radiation is emergence of cancer tumors, which happens as a result of oxidative DNA.  Therefore, the present study was conducted, aimed to measuring 8-DIHYDROxy- 2’- DEOXYGUANOSINE (8-OHdG) level in radiographers’ urine as oxidative damage biomarker, as well as comparing this biomarker with cumulative effective doses....

DNA Damage after High-LET Exposure

The number of tumor patients treated with carbon ions is increasing worldwide and even new therapy centres are planned. Therefore it is important to get a better understanding of high-LET particle induced DNA damage. It has been known for several years that DNA double strand breaks (DSBs) evoked by particle radiation are generally more slowly repaired than breaks induced by photon irradiation. ...

DNA Damage Responses following Exposure to Modulated Radiation Fields

During the delivery of advanced radiotherapy treatment techniques modulated beams are utilised to increase dose conformity across the target volume. Recent investigations have highlighted differential cellular responses to modulated radiation fields particularly in areas outside the primary treatment field that cannot be accounted for by scattered dose alone. In the present study, we determined...